Inna Lavrik, Otto von Guericke University, Magdeburg, Germany
Gerry Melino, Rome, Italy
The programmed cell death is essential property of all multicellular organisms. Its deregulation leads to a number of diseases, including cancer and neurodegeneration. The most common cell death pathways comprise apoptosis, necroptosis and autophagy. In the section the computational models of the cell death networks and their biological implications will be addressed. The central attention will be given to the models of extrinsic apoptotic pathways as exemplified models of apoptosis. The non-linear dynamics of the cell death networks, positive feedback loops and bistability as well as stoichiometric switches in apoptosis will be discussed. Furthermore, the current approaches of systems medicine will be presented involving the generation of new therapies connected to diseases with deregulation of cell death. Here special attention will be given to the target identification and development of small molecules specifically interacting with the key regulators of cell death networks.
The section supported by Russian Science Foundation grant “Programmed cell death induced via death receptors: Delineating molecular mechanisms of apoptosis initiation via molecular modeling” № 14-44-00011.